The best way to design would be to start from the heart of the product you are designing.

FORBES: How To Design Watches That Everyone Wants

"Start from the heart and work out, " Mr. DeStefano said.

WSJ: Road by Road, Plows Reopen Cities, Towns

Joos Valgaeren failed to recover from injury, allowing Stanislav Varga his first SPL start at the heart of the defence.

BBC: Victory not enough for Celtic

Despite several studies showing an association with alcohol intake and reduced cardiovascular risk, guidance from the American Heart Association warns people not to start drinking if they do not already drink alcohol.

BBC: NEWS | Health | Alcohol 'quickly' cuts heart risk

Since corporate change has to start from the top, a lack of biotech-savvy corporate governance may be at the heart of the issue: the reality is there are few if any biotech voices in Big Pharma boardrooms.

FORBES: Change Starts at the Top: Imperative to Bring Biotech Voices to Pharma Boardrooms

Set some ground rules before you start, at least in your own mind, because this is where your heart comes out from behind the computer screen.

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Owen, benefitting from Wayne Rooney's calf injury to make only his second league start for United, was at the heart of United's electrifying start.

BBC: Manchester United celebrate their opening goal