Brent Lewis, who runs Harlequin's digital business, says his firm's digital readership is composed of the same middle-aged women who read its printed books.
The syndrome was discovered by Dr Nobuo Kurokawa who, over the last 10 years, has been treating a steady flow of Japanese middle-aged women with the same symptoms.
Once a rare break from restrictive rules governing the behaviour of rural young women who were not allowed to sing aloud or go out at night, except during the Chuseok Thanksgiving celebration, the ritual is mostly preserved today by middle-aged women in cities and taught as part of the music curriculum of elementary schools.
Meningiomas represent about one-third of all primary brain tumors and are most frequently found in middle-aged women, the American Brain Tumor Association's website states.
And that audience gets what it wants within the first 10 minutes of Nancy Meyers' blithe, self-regarding, fitfully charming paean to the fairy-tale luck of middle-aged women wealthy enough to maintain a delightful standard of living after a divorce.
As female employment has risen and divorce become acceptable, there are probably fewer people who feel like that among middle-aged and older women, the groups that have seen the sharpest falls in suicide rates.
External stressors such as joblessness play a role. (National figures on whether suicides increased in the 2008 recession are not in yet, but suicides generally go up in bad economic times.) The very elderly once had the highest suicide rate, but middle-aged men and women, 45 to 54 (see graph, below), have surged recently and surpassed them.
There were four couples in their 20s, three mother-daughter pairs and two other clusters of women, one young, the other middle-aged.
The remaining state-owned enterprises are grey assemblies of middle-aged men and women, with retired former employees still living in company housing on upper floors.
She recalls two middle-aged women in traditionally-floral African dress nervously eyeing the mobile phones they had never used before in her first meetings to introduce the system.
There, I've said it: Middle-aged men and women and people old enough to be thanked by Willard on the "Today" show still want it all.
Had Cherry had his way, the leap in time would have been two years more, but he worried about telling a cast of middle-aged women they were going to have to age seven years.
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