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If England's Rugby Football Union is successful with its World Cup bid, having missed out to France in 2007, the 2015 tournament could see matches held at Twickenham, Wembley and the new Olympic Stadium.
BBC: London Mayor eyes Rugby World Cup
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This follows Tottenham's announcement last week that it wanted to demolish most of the Olympic stadium and build a new ground without a running track.
BBC: Olympic stadium
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Most important in the search for a new tenant is to avoid letting the venue fall into disrepair like the Olympic Stadium in Athens, which is now in shambles, abandoned and overgrown with weeds.
FORBES: West Ham United Likely To Win Bid For London Olympic Stadium
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"I don't think you can jump from a press conference where the new owners sit down and say we'd like to move to the to Olympic Stadium to how it might work, " she said.
BBC: Jowell plays down West Ham's Olympic Stadium hopes
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Spurs are hoping to move from White Hart Lane to either a new purpose-built ground close to the current site or the Olympic Stadium.
BBC: Sergei Bubka wants 2012 stadium promise honoured
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London would need a new stadium and Olympic village, to be sited in the east of the city, and transport links would also have to be upgraded by 2012, which is also the Queen's Diamond Jubilee year.
BBC: SPORT | Olympics 2004 | Olympics 2012 | Blair backs Olympic bid
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On the day West Ham's new co-owners, David Gold and David Sullivan, stepped up their bid to occupy the Olympic Stadium after the 2012 Games, the pair will be desperately hoping their club will still be in the top-flight to enjoy it.
BBC: West Ham 1-3 Wolverhampton Wanderers
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During the inspection of New York's bid, Mayor Michael Bloomberg told the International Olympic Committee's evaluation team he was confident the stadium would be built.
BBC: [an error occurred while processing this directive]
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"We understand the responsibilities that come with calling the nation's iconic Olympic Stadium, which will be converted into a world-class football stadium, our new home, " West Ham joint chairmen David Sullivan and David Gold said in a statement.
WSJ: West Ham Gets Olympic Stadium