For a few, an opportunity came during the replacements crisis at the time of the Bulge.
Hendre Fourie, who impressed on the flank in Moody's absence against Samoa, is among the replacements.
Kearney's inclusion in the replacements means that Ulster's Andrew Trimble drops out of the 22.
Wilkinson returns from injury and starts at loosehead, with Ronan Loughney included among the replacements.
Stade Francais lock Tom Palmer, who has trained with the team all week, comes onto the replacements' bench.
Uncapped Edinburgh back Jim Thompson is among the replacements for Andy Robinson's team.
BBC: Rory Lawson earns start for Scotland for Argentina Test
He was among the replacements in the Premiership final at Twickenham between current club Gloucester and future employers Leicester.
Knoyle's uncapped regional team-mate Josh Turnbull, the promising 22-year-old flanker, is one of four Scarlets on the replacements' bench.
The ineptitude of the replacements, in general, riled up football fans and provoked massive criticism from just about everyone else.
If McWhirter does miss out, Neil Best will come into the starting line-up with Rowan Frost drafted into the replacements.
It is a testimony to Hughes that the replacements were at the forefront of all that was good about City's performance.
Williams has been out of action since injuring his wrist in January, but is named among the replacements for the trip to Welford Road.
Geraghty, Deacon and Croft all drop to the bench while Sale back Mathew Tait is also among the replacements, as is fit-again prop David Wilson.
Deacon has started both of the autumn Tests but he is among the replacements after 20-year-old Courtney Lawes was released back to Northampton on Tuesday.
There is one change among the replacements for Samoa, with Bordeaux flanker Daniel Leo named on the bench in place of George Williams, who is injured.
The 19-year-old was among the replacements for last year's Millennium Magic game, but now he is one of the first names on coach Steve McNamara's team-sheet.
"Like Sandy said, we've just got to get ourselves ready and prepare ourselves with the guys who are going to be the replacements there, " Collins said.
Hailed in the 1980s as Canada's answer to Paul Westerberg, Soria performed with his post-punk band The Nils, which drew comparisons to Husker Du and The Replacements.
De Malmanche, who made his All Blacks debut coming off the bench against Italy in June, is likely to be named among the replacements for Saturday's contest.
But there is one change on the bench, with London Irish number eight Juan Martin Leguizamon returning from injury to nudge Martin Durand out of the replacements.
"I was obviously disappointed, but I'm part of a winning team at home, that's another good day, " said Jones, who admitted the "huge impact" made by the replacements.
Jones has been given the chance to lead the side at the Stadio Flaminio by coach Warren Gatland, with Ryan Jones named among the replacements for the Italy clash.
Ceri Sweeney started at fly-half in their 21-12 loss at Murrayfield ahead of Norton-Knight while Dai Flanagan, the other recognised fly-half at the Cardiff City Stadium, was on the replacements bench.
"These are licensed mechanics, " Boyd said of the replacements.
Jones and half-back partner Dwayne Peel start against the Azzurri after impressing off the bench in the 30-15 win over Scotland, with Hook and Mike Phillips taking their places among the replacements.
With Edinburgh centre De Luca among the replacements, Jim Thompson drops out of the squad, while Alasdair Dickinson has recovered from an abdominal upset to take Geoff Cross's place on the bench.
Glasgow were having a tough time in the scrums, but a change from the replacements bench seemed to put everything in order and immediately Hayes knocked over the second penalty in the 31st minute.
In what became a widely mocked symbol of the quality of officiating by the replacements, a photo from that game shows two officials in the end zone displaying competing signals: one indicating a touchdown, the other an interception.
And most important, to go through a period of retraining with all of the replacements and new personnel that would get in, so that the next time they went over they would go as a cohesive and well-trained team.
In terms of the departures and replacements at the top of the West Wing, yours and others, a lot of the candidates who are being mentioned or who are certain to take those roles are sort of coming from within the White House or within the general Obama sphere.
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