The main reasons for early sellouts seem to be short cycles of venture capital, and the significant change in lifestyle for first time founders after a sale.
But the most significant change was the shift in the balance of power across the Atlantic.
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The most significant change of the last 10 years is the emergence of consumers as the most powerful force in marketing.
But longtime Egyptian journalist Hani Shukrallah said that the most significant change is the one that has affected the minds of the voters.
Ed Davey, the Energy Secretary, put several elements of that in place today, saying the Bill is the most significant change to the energy market since privatisation.
Perhaps the most significant change of direction in the American debate comes from the result of last November's presidential election.
When it was launched in October 2010, organisers NE1 Ltd described it as the most significant change to retail opening hours since the introduction of Sunday trading.
The most significant change outlaws for-profit companies that sell debt-relief services over the telephone from charging fees before they settle or reduce credit-card or other unsecured debt.
Next up is the most significant change with Windows Phone 7.8, and Redmond's sole kudo: the ability to re-size Live Tiles.
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And with the turbulence, significant change in the advertising industry arrived.
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Still, the DGA timing may reduce the likelihood of significant change in the new media provisions of the contracts, unless the DGA is pushing for the same changes as well.
Sterling Smith, futures specialist, commodity research, Citibank Institutional Client Group, took a similar view as Barclays, saying it appeared that buyers stepped in at the low, which explained the lack of significant change in the data.
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The most significant change is that new ITINs will now expire after five years .
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Through their leadership and commitment we now have the first significant change in school meals in thirty years.
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This is "the most significant change we've made to our platform since we launched it four years ago, " Taylor said.
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On September 16, President Obama signed into law the Smith-Leahy America Invests Act (AIA), the first significant change in patent law since 1952.
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The most significant change, critics say, has been a clampdown on official information about crime, part of a government-wide attempt to refocus national and international attention onto Mexico's economy.
Bilsborough says the most recent significant change was in 2007 when the company removed artificial colourant from its chocolates.
The move represents a significant change in the Arab position.
The data will be pored over by scientists for years, but it was immediately clear from the information at hand that the object had experienced significant change since the Deep Impact observations.
According to Sam Walsh, the board is likely to approve the proposal, barring a significant change in the supply-demand situation by then or a major increase in production costs.
The researchers, who used a questionnaire designed exclusively for the study, found no significant change across the cycle in how the women perceived their level of commitment to the relationship or, at least initially, in their satisfaction with it.
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Levels of violent crime estimated by the Crime Survey showed no statistically significant change in the year.
The survey also showed "no significant change in the proportion of adults or children consuming the recommended daily intake of five or more portions of fruit and vegetables".
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My colleagues and I found that a jump in the price of gas causes a significant change in the kinds of cars that consumers buy and the price they pay for them.
And in the Democratic presidential contest, despite reports to the contrary, there has been no significant change in the candidates' polling numbers.
Contrary to the hysterics of the Obama opposition, the modification, which allows the Department of HHS to waive certain state requirements under the law, does not make any significant change in the substance of the law.
If the ruling party loses, it will be the first ideologically significant change in government in South Korea for several decades.
Bill Singer: Well, I just think that a lot of people fail to appreciate how significant the geopolitical change is that we're going through.
But this produced mixed results, with one state showing a statistically significant decline in general population mortality risk associated with the Medicaid expansion, while another showed a statistically significant increase in mortality risk and the third showing no statistically significant change.
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