On Sunday, he beat Rafael Nadal in the Rome Masters, his fourth-straight win over the Spaniard.
The Spaniard, who had heavy strapping on both knees, needed treatment for tendonitis during the match.
The Spaniard's father Emilio de Villota was also an F1 driver between 1976 and 1982.
"It was a tough match and I was never really close, " said the Spaniard.
The Spaniard has been out of work since being sacked by Inter Milan in January 2011.
And in the pit lanes the Spaniard could not even dismount his bike without assistance.
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The Spaniard's last defeat in this event was against Guillermo Coria 10 years ago.
"I think we're very happy as we know Friday means very little, " said the Spaniard.
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Vettel beat Ferrari's Fernando Alonso by 0.076 seconds, with the Spaniard's team-mate Felipe Massa in third.
The Spaniard did not face a single break point and lost just 10 points on serve.
But the Spaniard, despite making a perfect start, was not at his absolute best on Friday.
The Spaniard is joined by South Africa's Charl Schwartzel and America's Keegan Bradley and Michael Thompson.
The Spaniard now has a tour-leading 74 match wins this year, one more than Djokovic.
Wenger selected Fabregas despite the Spaniard's on-going fitness troubles and admitted it had been a gamble.
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The Spaniard won last year's Tour de France by 39 seconds from Luxembourg's Andy Schleck.
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"Sometimes you have to spend a little bit more, " the Spaniard told Press Association Sport.
After his shock defeat, the Spaniard took a prolonged break to recover from tendinitis in both knees.
The Spaniard, who has won the last eight Monte Carlo tournaments, starts his defense against Marinko Matosevic.
The Spaniard is ahead of British rider Bradley Smith and Italy's Andrea Iannone, who leads the championship.
The Spaniard showed no nerves as he struck the ball past Green to cap a magnificent display.
The Spaniard was surrounded by photographers prior to kick-off - always a bad sign for any manager.
The Spaniard, 24, won a rain-interrupted final 6-4 5-7 6-4 6-2 at Flushing Meadows in New York.
"We remain calm and optimistic, " said the Spaniard, who dropped from third to fourth in the championship.
Ferrari said the Spaniard had signed a three-year contract and that he would partner Brazilian Felipe Massa.
The Spaniard has previously raced in the World Touring Car championship and tested for Renault earlier this year.
The Spaniard also completed a race simulation run in the afternoon session, with a fastest lap of 1:21.669.
The Spaniard is looking to become the first man to win eight titles at the same Grand Slam tournament.
The Spaniard came closer when he turned Wallace inside the box and fired inches wide of the far post.
The Spaniard will face Juan Martin del Potro, who eliminated World No 1.
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The Spaniard's 71 left him 11-under par, one ahead of Wales' Garry Houston.
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