矿井瓦斯灾害与防治是煤矿生产面临的重大难题。
Disaster and prevention of gas is the major challenge of coal mine production faced.
据报道水资源缺乏将成为我国大城市的一个重大难题。
It is reported that water resource will be a big problem in large cities of our country.
“信用缺失”是我国现实经济运行中遇到的重大难题。
"Credit lack" is the great puzzle in the operation of our country's practical economy.
职业经理缺乏忠诚度是我国家族企业面临的重大难题。
The lack of professional manager loyalty is a significant problem Chinese family firms are facing.
次贷危机肆虐的当下，学费将成为家庭经济的重大难题。
Fees will be an even bigger worry this year as the subprime mess savages family finances.
如何选择合适的元件来实现系统芯片设计是目前面临的重大难题之一。
How to select appropriate components to implement the design of the SOC is a difficult problem to solve.
但是如何提高含永磁继电器的设计精度是研究人员面临的一个重大难题。
However, how to enhance the precision of the relay with permanent magnet's design is a great problem for the researchers.
橡胶行业密炼车间粉尘污染是长期未解决的重大难题，严重危害职工健康。
Dust pollution of smeltery of rubber industry is still an unsolved and harmful problem.
信用问题是经济理论研究中的新领域，也是现实经济运行中遇到的重大难题。
Credit issue is not only the new domain of economic theory study but the puzzle in the practical economic process as well.
如何制定有效的文化冲突管理措施是摆在跨国并购项目管理者面前的重大难题。
This thesis, just mentioned the severe point which is quite a tough issue for the project managers of international mergers.
抗逆转录病毒治疗药物价格昂贵、供应量少的现象仍然是摆在非洲企业雇主面前的重大难题。
An important hurdle for African employers remains the price and availability of ARVs.
信用体系的建设问题是经济理论研究的新领域，也是现实经济运行中遇到的重大难题。
The credit system construction problem is not only a new domain in the investigation of economic theory but also the great puzzle during the operation of practical economy.
多目标拦截是弹道导弹防御的重大难题，也是目前美国导弹防御系统所遇到的最大的技术难点。
Multitarget interception is a big difficult problem in ballistic missile defense, and is also the most arduous technology of the missile defense system of US.
然而，近几年来，煤矿事故却频繁发生，这成为我国煤矿生产安全管理工作面临的一个重大难题。
However, coalmine accidents do occur frequently recent years, it has always been a thorny problem to our country's administration of coalmine safety work.
崩落法开采急倾斜金属矿山的地表沉陷问题是国际性重大难题，属构造应力影响下地表移动问题。
The surface subsidence for caving mining used for metal mines with steep veins, a worldwide difficult problem, belongs to the realm of surface movement under the effect of tectonic stress.
研究背景与目的恶性肿瘤生长迅速，发病率及死亡率都相当高，已经成为威胁人类健康的重大难题。
Background and PurposeMalignant tumors, which are characterized by rapid growth, high morbidity and mortality, have become a major threat to human health.
怎样突破电子商务市场的支付手段的制约，一度成为业界最为关切的重大难题，也是学界研究的一大热点问题。
The breakthrough of the constraints has become not only the most difficult problem and bottleneck in development cared by the industry, but also a hot spot and focus to academic researchers.
怎样突破电子商务市场的支付手段的制约，一度成为业界最为关切的重大难题，也是学界研究的一大热点问题。
The breakthrough of the constraints has become not only the most difficult problem and bottleneck in development cared by the industry, but also a hot spot and focus to academic researchers.
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