Adapalene was synthesized from 4-bromophenol by alkylation, etherification, condensation and hydrolysis with an overall yield of 51%.
对溴苯酚经烷基化、硫酸二甲酯醚化、缩合及水解反应制得阿达帕林，总收率51%。
Adapalene was synthesized from 4-bromophenol by alkylation, etherification, condensation and hydrolysis with an overall yield of 51%.
对溴苯酚经烷基化、硫酸二甲酯醚化、缩合及水解反应制得阿达帕林，总收率51%。
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