A new HPLC method with fluorescence detector was developed and validated for the simultaneous determination of dextrorphan and guaifenesin in human plasma.
建立了灵敏度高、选择性好、可同时测定人血浆中右美沙芬活性代谢物去甲右美沙芬及愈创木酚甘油醚的HPLC-荧光检测法。
These appear today on medications that include dextromethorphan, a cough suppressant, the expectorant guaifenesin and the decongestants phenylephrine and pseudoephedrine.
如今，镇咳药右美沙芬、祛痰药愈创甘油醚以及解充血药苯福林和伪麻黄硷的包装盒上就标注了警告。
OBJECTIVE To establish a LC-MS/MS method for the simultaneous determination of guaifenesin, bromhexine, ambroxol in human plasma and to study their pharmacokinetics in healthy volunteers.
目的建立同时测定人血浆中愈创甘油醚、溴己新和氨溴索浓度的LC-MS/MS方法，并应用于人体药动学研究。
OBJECTIVE To establish a LC-MS/MS method for the simultaneous determination of guaifenesin, bromhexine, ambroxol in human plasma and to study their pharmacokinetics in healthy volunteers.
目的建立同时测定人血浆中愈创甘油醚、溴己新和氨溴索浓度的LC-MS/MS方法，并应用于人体药动学研究。
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