Global hypomethylation and regional hypermethylation are common mechanisms of aberrant expression of gene.
广泛的低甲基化和区域性高甲基化是基因异常表达的常见机制。
DNA hypomethylation often displays considerable specificity with regard to tumor type, tumor stage, and sequences affected.
DNA甲基化且与肿瘤类型、肿瘤分期及肿瘤侵袭的顺序中表现出相当的特异性。
But the mechanism isn't perfect: "If you look at tumors, they tend to have hypomethylation overall, but hypermethylation in some genes," Sapienza says.
但这种机制尚不完善：“如果你审视肿瘤，它们往往具备整体低甲基化，但某些基因却超甲基化，”萨皮恩扎说。
DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some t cell genes and development of autoimmunity in SLE.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。
Objective: To examine the extent of total genomic DNA methylation in hepatocellular carcinoma and the relationship between the DNA hypomethylation. and histopathologic characteristics.
目的：研究原发性肝细胞癌组织中总基因组DNA甲基化水平及其与病理学及生物学行为的关系。
The efficacy of hypomethylating agents (e. g. 5 aza 2′ deoxycytidine) as antineoplastic agents has been attributed to two distinct mechanism: cytotoxicity and induction of hypomethylation.
氮-2'-脱氧胞苷等去甲基化药物作为抗肿瘤药物的效应，归因于两种机制：细胞毒性和诱导低甲基化。
The efficacy of hypomethylating agents (e. g. 5 aza 2′ deoxycytidine) as antineoplastic agents has been attributed to two distinct mechanism: cytotoxicity and induction of hypomethylation.
氮-2'-脱氧胞苷等去甲基化药物作为抗肿瘤药物的效应，归因于两种机制：细胞毒性和诱导低甲基化。
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