If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.

双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。

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If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.

双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。

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