Quaternarization is an important SN2 nucleophilic substitution reaction; solvent has remarkable effect on it.
季铵化反应是一类重要的SN2亲核取代反应，溶剂对该反应的影响很显著。
Aripiprazole in overall yield of 68% was synthesized from 2, 3-dichloroaniline by a three-step nucleophilic substitution reaction in yield of 83%, 91% and 90%, respectively.
以2,3 -二氯苯胺为原料，经3步亲核取代反应合成了阿立哌唑。3步反应的收率分别为83%，91%和90%；总收率68%。
Five derivative dyes from the parent dyes were obtained by similar nucleophilic substitution reaction in which five primary amines were employed as the nucleophilic reagent.
将母体染料的中位氯原子用氨基试剂亲核取代，衍生合成了五个中位仲胺七甲川菁染料。
At the same time, discuss about the impact factor to nucleophilicity such as the number of attract electron group, ability of attract electron and the nucleophilic substitution reaction part.
并且对亲核试剂的体积效应、溶剂效应对亲核性影响，底物上吸电子基团的数目、吸电子能力对亲电性的影响，以及亲核取代反应的发生部位受哪些因素影响进行探讨。
METHODS: Electrophilic substitution, reduction, oxidation and nucleophilic addition reaction were used in the synthesis of title compounds.
方法：通过亲核取代、还原、氧化、亲核加成等反应得到目的化合物。
The key step of the two routes is the reaction of nucleophilic substitution of aromatic amines and -bromo compounds. Generally the produce rate of this reaction is low and the reaction time is long.
两条路线中关键的一步反应是芳胺和溴代化合物的亲核取代反应，一般这步反应产率很低，并且需要较长的反应时间。
Vicarious nucleophilic substitution (VNS) of hydrogen is a new type of reaction which is different from the usual electrophilic and nucleophilic reactions of the nitro arenes.
氢的替代亲核取代反应(VNS)是与硝基芳环的亲电反应、亲核反应不同的一种新反应。
Moclobelide was synthesized from ethanolamine by nucleophilic substitution and Schotten-Baumann reaction, followed by condensation with an overall yield of 71.2%.
以乙醇胺为起始原料，经亲核取代、肖特一鲍曼反应和缩合反应制得吗氯贝胺，总收率可达71.2%。
Moclobelide was synthesized from ethanolamine by nucleophilic substitution and Schotten-Baumann reaction, followed by condensation with an overall yield of 71.2%.
以乙醇胺为起始原料，经亲核取代、肖特一鲍曼反应和缩合反应制得吗氯贝胺，总收率可达71.2%。
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