Diaryl 1, 2, 4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor.
用作高选择性环加氧酶-2抑制剂的二芳基1,2,4 -三唑衍生物。
Objective To study the expression of cyclooxygenase-2 (COX-2) and HER-2 in human breast cancer and their relationship.
目的研究环氧化酶2 (COX 2)和表皮生长因子2 (HER 2)在乳腺癌中的表达及其相关性。
Objective To review the research progress of selective cyclooxygenase-2 (COX-2) inhibitors and anti-inflammatory herbs.
目的介绍选择性环氧化酶（COX）-2抑制剂与抗炎植物药研究概况。
To explore the relationship between the expression of cyclooxygenase-2 (COX-2) and angiogenesis in hepatocellular carcinoma.
目的探讨环氧合酶- 2 (COX - 2)表达与肝癌血管生成之间的关系。
Objective to clarify whether proton pump inhibitors (PPIs) stimulate Cyclooxygenase-2 (COX-2) expression in rat gastric mucosa.
目的探讨质子泵抑制剂(PPI)对大鼠胃粘膜环氧化酶—2 (COX - 2)表达的影响。
Objective To investigate the correlation between the expression of cyclooxygenase-2 (COX-2) in osteosarcoma and lung metastases.
目的探讨环氧合酶- 2 (COX - 2)蛋白在骨肉瘤中的表达与肺部转移的关系及临床意义。
Objective To investigate the expression of Cyclooxygenase-2 (COX-2) and its prognostic significance in oral squamous cell carcinoma.
目的调查环氧化酶- 2 (COX - 2)在口腔鳞状细胞癌中的表达及其预后意义。
Cyclooxygenase-2 (COX-2) inhibitors has recently received extensive attention for its role in prevention and inhibition of malignancies.
环氧合酶- 2 (COX - 2)抑制剂因其广泛的预防和抑制肿瘤作用，近年来得到人们的关注。
Objective To clarify cyclooxygenase-2(COX-2)expression and the effects of a specific cox-2 inhibitor in the healing of gastric mucosal damage.
目的探讨环氧化酶-2（COX-2）在胃粘膜的表达，和特异性COX-2抑制剂对胃粘膜损伤愈合的影响。
Objective: to investigate the effects of cyclooxygenase-2 (COX-2) inhibitor on TGF-b1 expression in human peritoneal mesothelial cells (HPMC).
目的：研究环氧化酶- 2 (COX - 2)抑制剂对人腹膜间皮细胞(HPMC)转化生长因子- 1 (TGF - 1)表达的影响。
Objective To study the expression of cyclooxygenase-2 (COX-2) in renal clear cell carcinoma tissues and its relation with the clinical tumor stage.
目的研究环氧化酶-2（COX-2）在人肾透明细胞癌组织中的表达，分析其表达水平与肿瘤分期的关系。
Conclusion Celecoxib may reduce the accumulation of prostaglandin E2 by inhibiting cyclooxygenase-2 activity, and thus inhibiting the expression of VEGF.
结论塞来昔布可能通过抑制环氧化酶2活性，减少前列腺素e2在大脑皮质中聚集，而抑制VEGF的表达。
Objective To observe behavioral changes and the dynamic expression of cyclooxygenase-1(COX-1) in the spinal cord of rats after unilateral sciatic cryoneurolysis(SCN).
目的观察大鼠坐骨神经冷冻（SCN）后行为学变化以及脊髓环氧化酶-1（COX-1）的表达。
Objective to reveal the relations between expression of cyclooxygenase-2 (COX-2) and tumor biological behavior and implications in tongue squamous cell carcinoma (TSCC).
目的探讨环氧化酶2 (COX 2)的表达与舌鳞癌生物学行为的关系及意义。
Objective: To investigate the influence of simulated occlusion pressure on the cyclooxygenase-2 (COX-2) gene expression in human periodontal ligament fibroblasts (HPLFs).
目的：观察模拟咬合压力对人牙周膜成纤维细胞环氧化酶2 (COX 2)基因表达的影响。
Aim: To investigate the diagnostic value of spiral CT and the correlation between spiral CT features and the expression of cyclooxygenase-2 (COX-2) in gastric carcinoma tissue.
目的：探讨螺旋CT对胃癌的诊断价值及螺旋CT征象与癌组织中环氧合酶- 2 (COX - 2)蛋白表达间的关系。
Objective To detect the clinical significance of changes of serum cyclooxygenase-2 (COX-2) activity and interleukin-18 (IL-18) in patients with T2DM diagnosed by the first time.
目的探讨初发2型糖尿病患者外周血中环氧化酶2（COX-2）活性与白介素18（IL-18）含量变化的临床意义。
Celecoxib as a cyclooxygenase-2 inhibitor, was synthesized from p-methylacetophenone and ethyl trifluoroacetate by successively condensation and cyclization in 67% overall yield.
以对甲苯乙酮和三氟醋酸乙酯为原料，经缩合、环合两步反应得到2型环氧酶抑制剂赛来昔布，总收率为6 7%。
The effect of cyclooxygenase-2 inhibitors and most nonsteroidal anti-inflammatory drugs (NSAIDs) on cardiovascular risk is not completely determined and should be studied further.
环氧化酶-2抑制剂和大多数的非甾体类消炎药（NSAIDs）的抗心血管疾病的效果并没有肯定，还需进一步研究。
Objective:To investigate the change of inflammation marker in the development of rats with pressure overloaded hypertrophy myocardium and influence of selective cyclooxygenase-2 inhibitor.
目的：观察代偿性心脏增大大鼠心肌肥厚过程中各种炎症反应标记物的动态变化及特异性环氧化酶-2抑制剂的影响。
Objective to investigate the effect of celecoxib on the cyclooxygenase-2 (COX-2) expression and the growth of orthotopic transplantation tumor in the case of experimental colorectal cancer.
目的探讨塞来昔布对实验性结肠癌原位移植瘤生长及环氧化酶- 2 (COX - 2)表达的影响。
Cyclooxygenase-2 (COX-2) and its metabolic products can be involved in the mechanism of the ischemic brain injury through destructing the vascular system, blood-brain barrier and the neuron.
环氧化酶- 2 (COX - 2)及其代谢产物可通过对脉管系统、血脑屏障和神经元本身的损伤，参与脑缺血再灌流后损伤的机制。
The progress on the study of its biological effect is promoting rapidly in recent years. This paper mainly reviews the advancement in the study of the cyclooxygenase-2 and leukemia angiogenesis.
其生物学效应的研究方面近些年进展迅速，本文主要就环氧化酶- 2与白血病血管新生的有关研究进展加以综述。
Also the combination of different target agents, such as combining the EGFR blockers - such as erlotinib and the cyclooxygenase-2 inhibitor (celecoxib) - needs to be investigated in clinical trials.
联合应用靶向因子如egfr阻滞剂-如厄罗替尼布和环氧化酶2抑制因子(塞来考昔)-还需要临床验证。
Now, new findings suggest that the drug achieves this by cutting off the tumor's blood supply, not just by blocking an enzyme called cyclooxygenase.
现在，新发现表明阿司匹林的这种作用不仅仅是通过阻断环氧合酶，而且还能切断肿瘤血液供应来实现的。
Objective to observe the effect of cyclooxygenase inhibitor on septic metabolism.
目的探讨环氧酶抑制剂对脓毒症时代谢反应的影响。
Celebrex and the other drugs, which largely target just cyclooxygenase, did not show these effects.
西乐葆和别的药物，仅仅作用于环氧合酶，并不具有这些作用。
Recent studies implicated expression of cyclooxygenase 2 (COX-2) as a marker to identify precursor cells for breast cancer.
最近的一些研究表明环氧化酶2 (COX - 2)的表达可以作为发现乳腺癌细胞的标记。
The inhibitory function of ginger on platelet aggregation were related with cyclooxygenase activity.
姜抑制血小板聚集的作用与抑制环氧化酶活性有关。
Objective To study the expression of cyclooxygenase -2 (COX-2) in skin carcinoma and its clinical significance.
目的探讨环氧合酶2 (COX 2)在皮肤肿瘤组织中的表达及其临床意义。
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