If you can genetically engineer viruses like this and viruses have all those good properties as gene therapy vehicles that I described.

如果你能像我说的这样在遗传上改造病毒,加之病毒具备诸多优点,适合作为基因治疗的载体

耶鲁公开课 - 生物医学工程探索课程节选

So, making gene therapy specific is a key problem in making it work.

所以基因治疗中,特异性对能否成功就至关重要了

耶鲁公开课 - 生物医学工程探索课程节选

Because of this, because cystic fibrosis is a disease that's caused by a single gene defect, there's been great interest in trying to treat cystic fibrosis with gene therapy.

就是因为如此,就因为囊胞性纤维症,是一种单基因病,人们对于用基因治疗,治愈囊胞性纤维症产生了很大的兴趣

耶鲁公开课 - 生物医学工程探索课程节选

That's another advantage of using viruses as a gene therapy vector.

这是病毒,作为基因疗法载体的另一个优势

耶鲁公开课 - 生物医学工程探索课程节选

Why isn't that the solution to gene therapy?

但病毒为什么不是基因治疗的解决方案呢

耶鲁公开课 - 生物医学工程探索课程节选

That is also an advantage of using them as gene therapy vehicles because they will only infect cells that they are - that they have an affinity for or that they're prone to affect.

非常有利于将其,作为基因治疗的载体使用,因为它们只能感染那些--,它们对之具有亲和性,或者说它们倾向于去感染的细胞

耶鲁公开课 - 生物医学工程探索课程节选

Before we talk about how to do it-- and we don't have perfect ways to do it yet but I'll describe some of the ways that are used, I want to talk just briefly on this slide about what the goals for gene therapy might be.

在讲具体怎么做之前--,现在还没有任何一种方法是完美的,但我还是要讲讲一些已经应用的方法,我借助这张幻灯片简要介绍一下,基因治疗的可能目标

耶鲁公开课 - 生物医学工程探索课程节选

I talked about just not using viruses but using plasmid DNA together with lipids and that's another strategy for gene therapy.

这一部分我们不仅讲了病毒的应用,也讲了利用脂质体包裹的质粒DNA,基因治疗还有其它的策略

耶鲁公开课 - 生物医学工程探索课程节选

So in the first week we run a section called from strawberries to gene therapy where we talk about DNA, extract DNA, you can play with the DNA of an organism and we can think about how to use DNA for other purposes.

第一周组会的主题是从草莓到基因疗法,主要讨论DNA和DNA的提取,使你们对有机组织的DNA有直观的认识,并思考DNA的其它应用

耶鲁公开课 - 生物医学工程探索课程节选