The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme.
与天然存在的野生型酮还原酶相比，本公开提供了具有改善的性质的酮还原酶。
The authors found that mice lacking CD24, a membrane protein expressed by immune and stem cells, developed an inflammatory response that was more powerful and lethal than that in wild-type mice.
作者们发现，缺乏CD 24，这种在免疫细胞和干细胞上表达的膜蛋白的老鼠，产生了比野生型老鼠更强且更致命的炎症反应。
An important safety issue related to the varicella vaccine is the impact on the epidemiology of herpes zoster both in vaccinees as well as in individuals previously infected with wild-type varicella.
与水痘相关的一个重要的安全性问题是其对带状疱疹的流行病学的影响—这种影响既见于受接种者，也见于既往曾感染过野生型水痘的个体。
Male wild-type mice had twice the ALT levels (P < . 05 in both cases).
雄性野生种小鼠的此数值为2倍（P <.05）。
Objective To study the antigenic variation of wild-type measles virus prevailing in Zhejiang Province.
目的了解浙江省麻疹野毒株的抗原性变异状况。
Complete response rates were similar for children with either mutation and children with wild-type FLT3, the authors report.
作者报道，有突变患儿和野生型FLT3患儿的完全有效率是相似的。
Clinical and pathological variables, copy number alterations, mutations, and expression signatures were compared with a cohort of TCEB1 wild-type tumors.
就肿瘤的临床及病理特征、染色体拷贝数量改变、突变和表达特征等方面与TCEB1野生型肿瘤进行比较。
Infection assay of mutants on Chinese differential host shows that virulence of all the mutants changes significantly in contrast with wild-type isolates.
采用中国鉴别寄主对突变体的毒性研究表明，各突变菌株的毒性均较原始菌系发生了明显改变。
Recessive allelic variations were investigated at 3 microsatellite (SSR) sites within the o2 gene by using 14 inbred o2 lines and a wild-type line in maize.
用14个O2玉米自交系和1个普通玉米自交系研究玉米o2基因内3个微卫星(SSR)位点的隐性等位变异。
Female wild-type mice on an ethanol-rich diet had 4 times as much alanine aminotransferase (ALT), indicating liver injury, than mice lacking the osteopontin gene.
雌性野生种小鼠的丙氨酸转氨酶是基因敲除鼠的4倍，这提示肝损伤的存在；
As detected by Western blotting, TRPV1 expressions in the brain and skeletal muscle of the transgenic mice were significantly higher than the wild-type littermates.
经蛋白免疫印记法证实，与同窝野生型小鼠相比，转基因小鼠的脑组织和肌肉组织中TRPV1的表达显著升高。
By using the assay, pigs infected with wild-type CSFV can be identified and removed from the vaccinated population, which will help to establish a CSF-free swineherd.
可以将CSFV野毒感染猪迅速从免疫猪群中筛查出来并予以清除，有利于猪瘟的净化和无猪瘟疫区的建立；
Conclusion Transfection of wild-type PTEN tumor suppressor gene might significantly reduce metastatic ability of human highly metastatic mucoepidermoid carcinoma cells.
结论转染野生型PTEN抑癌基因能降低人高转移性黏液表皮样癌细胞转移能力。
Objective To study effects of the exogenous wild-type PTEN tumor suppressor gene on in vitro adhesion, migration and invasion of the highly metastatic mucoepidermoid carcinoma cell line M3SP2.
目的探讨外源野生型PTEN抑癌基因对人高转移性黏液表皮样癌细胞系m 3sp2体外黏附、迁移和侵袭特性的影响。
Conclusions Wild-type measles virus prevailing in Zhejiang Province has appeared significant antigenic variation.
结论浙江省麻疹野毒株已出现明显的抗原性变异。
All three mutants showed higher luciferase activity than that of the wild type, and the V85I mutant showed the highest activity.
三个突变异种均显示比野生型具有更高的荧光素酶活性，并且V85I突变异种活性最强。
When the DNA was methylated the chromosome was able to be successfully transplanted into a wild type species of M. capricolum.
当DNA甲基化后，染色体能够顺利植入野生型的丝状支原体。
The variant cell line also expressed high level of cross resistance to ethionine which was 6.5 fold higher than that of the wild type.
同时还表现出对乙硫氨酸的交叉抗性，其抗性是野生型的6．5倍， 表明该抗性系抗性表达稳定。
Conclusion Construction of the eukaryotic expression vectors of wild type and mutant PRPF31 genes is basic work for research on the mechanisms of retinitis pigmentosa caused by PRPF31 mutation.
结论野生型和突变型PRPF31基因真核表达载体的构建，为研究PRPF31基因突变引起视网膜色素变性的机制奠定了基础。
Objective to construct the expression vectors of human cytochrome P450 (CYP) 4f2 wild type, V81G and V433M Variants and express and purify CYP4F2 protein in e.
目的构建人细胞色素P450 4f 2基因野生型、V81G和V433 M突变型表达载体，在大肠杆菌中表达并纯化出CYP4F2蛋白。
The growth and maturation of the green mutant were relatively slower than the wild type.
绿色突变体的生长和成熟均比野生型慢。
But wild type GFP and EGFP are not ideal to detect the transient changes of gene expression regulation.
但野生型GFP及增强型GFP等因半衰期长，稳定性强，对反映一过性转录表达调控的变化不甚理想。
They all accumulated on the surface of rice root system in the medium with higher ammonia concentration, while the wild type strains were removed from rice root surface in the same condition.
这些转化结合子在高铵下表现出固氮活性，并能集聚在水稻根表，而野生型菌在相同条件下远离水稻根表。
Four cases have been confirmed to have been caused by wild poliovirus type 1 and laboratory testing continues.
经确认，四例病例由1型野生脊灰病毒引起，实验室检测还在继续。
On 20 April, four polio cases due to wild poliovirus type 1 were confirmed in Yemen.
4月20日，在也门由1型野生脊髓灰质炎病毒造成的4例脊髓灰质炎病例得到确认。
The Ministry of Health of the Republic of Tajikistan has since 1 January 2010 reported 430 cases of polio following the importation of a wild poliovirus type 1 into the country.
发生1型野生脊髓灰质炎病毒输入病例之后，塔吉克斯坦共和国卫生部自2010年1月1日以来报告发生了430例脊髓灰质炎病例。
On 20 April, results of testing of stool specimens of four of the cases by the polio network laboratory in Oman revealed wild poliovirus type 1.
4月20日，在阿曼的脊髓灰质炎网络实验室对这些病例中的4例粪便标本检测的结果显示1型野生脊髓灰质炎病毒。
As of 19 July the Ministry of Health of Angola has reported 15 cases of wild poliovirus type 1 (WPV1) since the beginning of 2010, signalling an expansion of an ongoing outbreak.
截至7月19日，安哥拉卫生部自2010年初以来已经报告发生了15例1型野生脊髓灰质炎病毒病例，这表明正在发生的疫情有所扩大。
Pakistan is affected by nationwide transmission of WPV1, and is the location of the only wild poliovirus type 3 (WPV3) case in Asia in 2011 (a strain on the verge of elimination on the continent).
巴基斯坦全国受到1型野生脊灰病毒传播的影响，并且是2011年在亚洲出现唯一一例3型野生脊灰病毒(在亚洲已濒临消除的一个毒株)病例的地方。
July 2010 - as of 19 July the Ministry of Health of Angola has reported 15 cases of wild poliovirus type 1 (WPV1) since the beginning of 2010, signalling an expansion of an ongoing outbreak.
2010年7月19日-截至7月19日，安哥拉卫生部自2010年初以来已经报告发生了15例1型野生脊髓灰质炎病毒病例，这表明正在发生的疫情有所扩大。
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