OBJECTIVE: Preparation of compound aciclovir gel and establish a method of quality control by HPLC.
目的：制备复方阿昔洛韦凝胶并建立其质量控制方法。
Results: no irritation of aciclovir gel on the integral or damaged skin of rabbit was observed. Sensitization effect on the skin of guinea pig was not found.
结果：阿昔洛韦凝胶对家兔完整皮肤和破损皮肤均无刺激性，对豚鼠完整皮肤无致敏性。
Objective To study the effect of different solvent systems on in vitro penetration rate of aciclovir gel enhanced by Azone for optimizing the formulation of aciclovir gel.
目的研究阿昔洛韦凝胶中的不同溶剂系统对主药体外透皮速率及对氮酮促渗作用的影响，为优化阿昔洛韦凝胶处方提供实验依据。
RESULTS: the releasing curve of the aciclovir eye gel in vitro was in line with the first-order drug releasing equation.
结果：阿昔洛韦眼用凝胶体外释放曲线符合一级释药方程。
METHODS The aciclovir eye ointment was used as control group, and the gel as test group, the drug action on treatment of experimental rabbits herpes simplex keratitis (HSK) was compared.
方法：选用市售阿昔洛韦眼膏作为对照组，阿昔洛韦眼用凝胶剂为实验组，比较两者治疗实验性家兔单纯疱疹性角膜炎的药效差异。
METHODS The aciclovir eye ointment was used as control group, and the gel as test group, the drug action on treatment of experimental rabbits herpes simplex keratitis (HSK) was compared.
方法：选用市售阿昔洛韦眼膏作为对照组，阿昔洛韦眼用凝胶剂为实验组，比较两者治疗实验性家兔单纯疱疹性角膜炎的药效差异。
应用推荐