However, their therapeutic use is often hindered by problems such us poor water solubility, acquired drug-resistance and strong toxicity.
但由于水溶性差、易产生多药耐药性和毒性较强等缺点限制了它们在临床上的应用。
Alternatively, acquired drug resistance results when tumors initially respond to therapy but become refractory to subsequent treatments.
或者，当肿瘤最初响应于治疗但对随后的治疗变得难以治愈时，就会导致获得性耐药性。
The varieties of antibiotics are used widely and the bacterial drug resistance appears greatly. P. aeruginosa have acquired a great resistance and multiple resistance by many methods.
由于各种抗生素的广泛使用，细菌耐药问题日趋严重，导致了铜绿假单胞菌产生了很强的耐药性而且多重耐药，铜绿假单胞菌通过多种途径产生耐药。
The varieties of antibiotics are used widely and the bacterial drug resistance appears greatly. P. aeruginosa have acquired a great resistance and multiple resistance by many methods.
由于各种抗生素的广泛使用，细菌耐药问题日趋严重，导致了铜绿假单胞菌产生了很强的耐药性而且多重耐药，铜绿假单胞菌通过多种途径产生耐药。
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