• RESULTS SODN inhibited the growth of CNE1 and CNE2Z cells as well as ASODN, and presented dose and time dependent manner.

    结果端粒酶正义寡核苷酸与反义寡核苷酸一样可抑制鼻咽癌cne1CNE2 Z细胞生长,且呈剂量时间依赖性。

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  • Results The growth of human orbital rhabdomyosarcoma in nude mice was inhibited in the ASODN NP group obviously ( P< 0.05);

    结果与其他两相比,ASODN NP组肿瘤生长明显受到抑制(P<0.05);

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  • To study the inhibitory effect of bcl-2 antisense oligonucleotide (ASODN) combined with radiation on lung carcinoma cells NCI-H446.

    研究Bcl - 2反义寡核苷酸联合照射肺癌细胞的抑制作用。

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  • Conclusion ASODN can suppress endothelial cell growth and inhibit tumor angiogenesis possibly by specifically blocking VEGF expression in thyroid carcinoma.

    结论ASODN通过特异性封闭甲状腺癌细胞VEGF表达抑制内皮细胞生长干扰肿瘤血管生成。

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  • AIM: to investigate the effect of antisense oligonucleotides (ASODN) encoding telomerase reverse transcriptase (TERT) mRNA on thyroid carcinoma (TC) cell apoptosis.

    目的探讨逆转录酶(TERT)反义寡核苷酸(A SODN)甲状腺(TC)细胞凋亡影响

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  • The result showed that VEGF ASODN had obviously inhibitive effect on expression of VEGF in U937 cell, as compared with scrambled sequence and negative control (P<0.05).

    结果显示VEGFASODNU937细胞VEGF的表达有明显的抑制作用,错义序列组空白对照组相比有显著差异(P<0 .0 5 ) ;

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  • Objective to investigate the effects of keratinocyte growth factor (KGF) and KGF receptor (KGFR) antisense oligonucleotide (ASODN) on cell cycle and apoptosis of HaCat cells.

    目的研究角质形成细胞生长因子(KGF)及其受体(KGFR)反义核苷酸KGF介导细胞周期凋亡变化的抑制作用。

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  • Methods To set up HER-2 antisense oligodeoxynucleotides (ASODN) experimental group, sense oligodeoxynucleotides (SODN) group, folate acid (FA) group and 60Co irradiation control group.

    方法实验分组如下:HER-2反义脱氧核苷酸、HER-2正义寡脱氧核苷酸组、叶酸对照组空白对照组。

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  • ConclusionSTAT3 ASODN not only possess chemotherapeutic effect, but also can improve the sensitivity of tumor cells, making it a promising agent for future research and clinical application.

    结论反义STAT 3具有化疗效果具备放疗增作用,对提高肿瘤放疗效果有良好的开发前景。

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  • The lens posterior capsule was covered by a layer of lens epithelium in the control group, while the lens epithelium could hardly been observed on the lens posterior capsule in the ASODN group.

    对照组晶体覆盖晶体上皮细胞,ASODN晶体后囊前无明显晶体上皮细胞增殖。

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  • The lens posterior capsule was covered by a layer of lens epithelium in the control group, while the lens epithelium could hardly been observed on the lens posterior capsule in the ASODN group.

    对照组晶体覆盖晶体上皮细胞,ASODN晶体后囊前无明显晶体上皮细胞增殖。

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