Objective:To explore the application of the generalized estimating equation (GEE)in the repeated measures data.
目的：探讨广义估计方程在临床试验重复测量资料分析中的应用。
Objective: To explore the application of the mixed linear model in the repeated measures data of clinical trials.
前言：目的：探讨混合线性模型在临床试验重复测量资料分析中的应用。
Method: the repeated measures data were analyzed with category variance outcome by GEE and conclusions were drawn according to the estimating of parameter and standard error.
方法：利用广义估计方程分析结果指标为分类变量的重复测量资料，通过参数和标准误的估计得出统计学结论。
CONCLUSION: multivariate random coefficients model can effectively analyze the dynamic change trend and random effects of multivariate repeated measures data in medical research.
结论：多变量随机系数模型可有效地进行多变量重复观测数据的动态变化趋势分析以及随机效应分析。
CONCLUSION: multivariate random coefficients model can effectively analyze the dynamic change trend and random effects of multivariate repeated measures data in medical research.
结论：多变量随机系数模型可有效地进行多变量重复观测数据的动态变化趋势分析以及随机效应分析。
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