This can lead to complications such as heart disease, stroke, kidney disease, blindness, and lower-limb amputation.

Background venous thromboembolic disease, including deep venous thrombosis and pulmonary embolism, is a serious and potentially life-threatening complication following orthopaedic surgical procedures.

Every 30 minutes a diabetic patient loses the use of his bottom limb due to the ulceration of tissues that degenerates into a necrosis, which is a typical side effect of this disease.