Objective to investigate the role of reactive oxygen species (ROS) and ROS-caused mitochondrial transmembrane potential loss in sodium selenite-induced apoptosis in NB4 cells.

To increasing the curative effects of druggery, decreasing drug - resistance, it is necessary get more advance investigation on adding effects of Sodium selenite and All - trans Retinoic acid.

The anti leukemia effects of organic selenium compound and inorganic selenium compound-sodium selenite were studied in K562 cells in culture with MTT colorimetric assay.