Although the treatment of this disease is not easy, on the other hand the high quality curative treatment, safe, low invasive and low cost treatments are required for the patients.

By analyzed with immunohistochemistry in 45 HCCs, the MMP-1 expression in HCCs with invasion or metastasis is higher than that without invasion and metastasis (P0.05).

The high expression of Angiopoietin-2 and low expression of E-Cadherin maybe be regarded as an index screening liver carcinoma of strongly potential invasion and high frequent metastasis.