Methods Microarray analysis on human signal transduction associated proteins was applied to profile changes in gene expression of human ECV304 endothelial cells induced by low density lipoprotein.

This work demonstrates the role of OxLDL in the expression of the OPN gene and further highlights the role of oxidative stress in the regulation of this cytokine.

There is increasing evidence that lipid peroxidation and oxidative modification of low density lipoprotein is important in atherogenesis.