For example, working on HIV prevention with injecting drug users in Afghanistan and Pakistan would benefit from coordination with similar initiatives in Iran and Central Asia.

These are risks like HIV infection, malnutrition, diabetes, smoking, alcohol and substance abuse, indoor air pollution and, above all, limited access to basic care for the poorest people.

Exuding a beguiling mix of confidence and fragility, it was Jolie's first chance to essay a character on the verge of a breakdown, as Gia goes from overnight success to HIV-infected drug addict.