基因组不稳定性

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genomic instability
DNA聚合酶β高表达与基因组不稳定性的关系 - 生命科学-科研基金网关键词：DNA聚合酶β,基因组不稳定性,细胞周期，DNA损伤 [gap=1456]Keywords：DNA polymerase beta;genomic instability; Cell cycle；DNA damage
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GI
...作者:戴纪刚,张在永 9卷第22期作者: 戴纪刚, 张在永学术期刊 QCode : cqyx201022057 基因组不稳定性(genome instability,GI)是肿瘤细胞的主要特征,它在肿瘤的发生和发展过程中起重要作用.

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结论黑色素瘤的发生可能与基因组不稳定性有关。
Conclusion The occurrence of melanoma might be associated with genetic genomic instability.
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有很多原因可以解释，包括：乏氧驱使基因组不稳定性及改变DNA损伤修复通路的能力。
There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways.
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依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。
Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).

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