With intratracheal instillation method, 3 Escherichia coli strains isolated from this hospital were used to establish neutropenic- rat pneumonia model.

E. coli showed low drug resistance ratio to carbapenem, cephamycins, amikacin and furadantin, and Klebsiella pneumoniae showed a good sensitivity to most of the antibiotics.

Results Among 38 strains, 32 strains were Gram-negative bacilli(84.21%), including 9 strains of escherichia coli, 8 strains of pseudomonas aeruginosa and 8 strains of bacillus canalis capsulatus.