A total of 358 patients with severe aortic stenosis, a heart disease characterized by obstruction of the aortic valve due to calcification, participated in the trial.
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Jana Pausa, 76岁，加利福尼亚州阿瑟顿人，有严重主动脉瓣狭窄和使她不适合开心手术置换病损心脏瓣膜的肺部疾病，是一个这样的病例。
Jana Pausa, 76, of Atherton, Calif., who had both severe aortic stenosis and lung disease that made her unsuitable for open-heart surgery to replace the diseased heart valve, is one such patient.
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