Objective: To study the protective roles of Chlorpromazine on nerve functions of SD rats with brain injury.

Conclusion quetiapine has less side-effect and superior to chlorpromazine in the life quality for schizophrenics quetiapine is favorable for schizophrenic patients to recovery and return to society.

Compared with chlorpromazine, clonidine was less effective in producing sedation, however, it produced anti-depression effect with fewer adverse drug reactions.