Conclusions-: These findings indicate that MRP1 and LTC4 exert proatherosclerotic effects and that both MRP1 and LTC4 are potentially promising targets for atheroprotective therapy.
3
初步药理结果表明化合物(51),(68),(89)和(95)对白三烯D_4受体有较好的拮抗作用。
Pharmacological tests showed that compounds (51), (68), ( 89) and (95) have strong antagonism on the D4 recepter of Leukotriene (LTD4).