He and his wife, already parents of a child with cystic fibrosis, had gotten word that their second baby, due later this year, would almost certainly have Down syndrome.

Wong She, Yip Sang's second wife, was very young with "sensitive" eyes, but did not meet with the approval of Lee Shee.

Likewise, if your second toe is longer than the big toe (a condition known as Morton's toe), this could cause a weight imbalance resulting in back pain.