Objective To observe and compare the volumes and survival periods of tumors in the patients with advanced liver cancer after treatments of transhepatic arterial infusion and heat infusion.

Results A-NK cells could significantly prolong the survival time of the model mice, in comparison to the LAK cells, there was statistically significant difference (P<0.01).

The improvement insurvival facilitated by sorafenib, even though modest, was a major advance for the treatment of HCC, and stimulated drug development in first line treatment of HCC.