The foundations are the Bleeding due to blood-heat , Qi failing to control blood , the Yang deficiency of spleen and renal, the Yin deficiency of liver and renal, and the deficiency of blood.

OBJECTIVE To study the effects of warm and tonify kidney-yang herbs on the liver mitochondria proteome of the kidney-yang deficiency rats by two-dimensional difference gel electrophoresis (2-D DIGE) .

Weakness of the spleen and stomach and liver depression and Qi stagnation were more popular in young patients, kidney-Yang deficiency was more common in older patients;