Conclusions Senile patients with lung cancer demonstrated atypical symptoms and their prognosis and lifetimes are related to clinical stages and histological styles with no relation to ages.

Objective To investigate the clinical characteristics and diagnosis of lung cancer with paraneoplastic syndrome as initial symptom.

Conclusion: Aiyishu injection could alleviate the symptoms, improve the quality of life in the advanced NSCLC patients. Aiyishu injection could reduce the toxicity of chemotherapy.