The dysfunction of insulin-signaling transmission weakens insulin physiological function, and leads to insulin resistance and T2DM.
2
目的探讨超生理浓度的血浆葡萄糖对胰岛素分泌功能及外周组织胰岛素敏感性的作用。
Objective To study the effects of supraphysiologic concentration of plasma glucose on pancreatic islets secretion and peripheral tissue sensibility to insulin.
3
如果刺激时间延长到14天，非生理浓度葡萄糖均表现为胰岛素基因的抑制作用。
When islets were stimulated as long as 14 days, all non-physiologic concentrations of glucose showed suppressive effects in insulin gene expression in a dose-dependent manner.
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