Others, Pons infarction in 5 cases, cerebellar infarction in 3 cases, cerebral hemisphere or base ganglion infarction in 8 cases, and leukoencephalopathy in 6 cases.

It was related to the dosage and time. Along with the time extension and the cuprizone dosage increasement, the cell apoptosis increased and the demyelination aggravated.

Abnormal enhancement is not seen in PMD as opposed to some demyelinating disorders such as adrenal leukodystrophy in which enhancement is seen at the periphery of the active demyelination.