The spleen can affect the platelet count, the red blood cell count and even the white blood count.

Rigel's kinase inhibitor, called fostamatinib, targets spleen tyrosine kinase, which among other functions enables the formation of the large immune-cell complexes found in autoimmune diseases.

Objective To investigate the role of splenic macrophage in the occurrence of hypersplenism in patients with portal hypertension.