Microscopially, adenoacanthoma consists of two components, adenocarcinoma and squamous cell carcinoma.

The results showed that each group of keratinizing and non-keratinizing. squamous cell carcinoma and adenocarcinoma cell plasma have an average orientation which mean a relative constant hue.

Combination method of CYFRA 21-1 and NSE or CEA could make the detection rate to 100% for small cell cancer, and it could elevate the detection rate for adenocarcinoma and squamous cancer.