Background venous thromboembolic disease, including deep venous thrombosis and pulmonary embolism, is a serious and potentially life-threatening complication following orthopaedic surgical procedures.

Thromboembolism disease is a frequent complication of malignant tumor, which is closely associated with the progression, therapy and prognosis of cancer.

The difference in the goal INR is based on risk versus benefit between prophylaxis against thromboembolic disease and bleeding risk.