However, patients with CD in remission fare much better than those with persistence of hypercortisolism, and they appear not to have an increased mortality rate.

Depression and mania were the main manifestations of psychosis in the patients, and 79.7% of the patients showed symptoms of depression.

Conclusion These changes might be caused by the inhibitory effects of hypercorticordism on the activity of 5′-deiodinase and the secretion of pituitary TSH.