Methods: HPMC and stearic acid were used to prepare melatonin controlled-release bilayer tablets by application of solid dispersion method and double compression technology.
2
采用以正交设计优化处方;粉末直接压片法制备褪黑素口腔崩解片。
The prescription was optimized by means of orthogonal design and the melatonin ODTs were prepared by press the powder directly.
3
采用恒温加速试验对褪黑素口腔崩解片进行稳定性的考察。
The stability of tablet was determined by a homoiothermic acceleration test.