Objective To summarize the clinical characteristics, treatment and prognosis of severe hand-foot-mouth disease combined with encephalitis.

Objective To discuss the therapeutic effect of high dose methylprednisolone impaction in the treatment of severe hand-foot-mouth disease.

Conclusions: the diagnosis and treatment should be paid more attention on, especially for severe patients with complication. Theearlier is the therapy carried out, the better is the prognosis.