Information available suggests that effects of estrogen on bladder cancer are inhibition, while the opposite role of androgen. A specific molecular mechanism remains unclear.

Tibolone, a synthetic selective tissue estrogenic activity regulator (STEAR), has estrogenic, progestogenic, and androgenic effects, the authors write.

Basically what it does is up-regulate PGE2 which AIDS in hair growth, suppresses androgen receptor related functions, promotes maintenance, and significantly improves the functions of hair follicles.