Very high androgen levels may cause male-like balding, deepening of the voice, and increased muscle mass.

The "superactive AR"hypothesis was supported by the fact that the majority of AIPC expresses high level of AR and nuclear receptor(NR) coactivators, such as TIF-2, ARA24, PIAS, SRC-1.

Objective To investigate the effects of androgen and high-fat diet on ultrastructures of ovary, pituitary and adrenal in female SD rats.