据报道水资源缺乏将成为我国大城市的一个重大难题。
It is reported that water resource will be a big problem in large cities of our country.
次贷危机肆虐的当下，学费将成为家庭经济的重大难题。
Fees will be an even bigger worry this year as the subprime mess savages family finances.
如何选择合适的元件来实现系统芯片设计是目前面临的重大难题之一。
How to select appropriate components to implement the design of the SOC is a difficult problem to solve.
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