IMA is not specific for cardiac ischemia. IMA is also elevated in most patients with liver cirrhosis, acute infections and advanced cancers; all these conditions are potent producers of free radicals.
IMA并不单单存在于心肌缺血的患者,它在肝硬化,急性传染病和晚期癌症患者身上也呈现高浓度——这些疾病都能生产大量自由基。
TGF ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers.
TGF配体虽然在早期肿瘤中作为肿瘤抑制基因发挥作用,但其在进展期肿瘤中却变成有效的促转移因子。
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