You must draw a line in the sand and confess that you're sick and tired of being sick and tired, before you will be able to go forward.

你必须在地上划一条线，在你生病和疲倦时承认你生病和疲倦，直到你可以重新出发。

youdao

In order to gain control of your emotions and combat the feeling of being sick and tired, wherever you find yourself, resting can't be overlooked.

为了控制你的情绪，战胜你的病态和劳累，找到自我，休息是不容忽视的。

youdao

You must be so tired and sick of doing this every day.

你每天都这样，一定已经累得想吐了吧？

youdao

It could be that traders and investors are just sick and tired of trying to assess the whole situation.

FORBES: Comex Gold Slightly Lower Amid Firmer U.S. Dollar Index, Weaker Crude Oil Prices

By 2008 Americans will be tired of President Bush and sick of Republicans.

FORBES: Should Republicans Punt the House?

If they stay in place, that means instead of dismantling the infrastructure of militant organizations, they will be backed by thousands of young men, who are desperate and who are sick and tired with the Israeli occupation and with the international community.

NPR: Israel May Sever Israeli, Palestinian Road Links