Despite some limitations of trial design, including the open label nature of the study, RECORD remains the only randomized trial of cardiovascular outcomes for Avandia at this time.
Unfortunately, the reviewers found that limitations in the design of the trials, their conduct, and the way they were reported precluded any conclusions about the effect of the drug on complications.
The limitations of responsive design in adapting for use case and context means that it is more hindrance than help in mobilizing distinct, device-specific experiences that impart user value, such as more complicated web applications.