You're losing a chance of a lifetime.

你要失去千载难逢的好机会哦。

youdao

It would be foolish to let such an opportunity slip; it's a chance of a lifetime.

坐失这个良机，那真是太傻了，这是一生中难得的机会。

youdao

Ain't Nothin 'But a Winner: Bear Bryant, the Goal Line Stand, and a Chance of a Lifetime.

不是一无所有，而是胜利者：比尔·布赖恩特，背水一战，一生的机会。

youdao

For him, coming to America to attend George Washington University was the chance of a lifetime.

VOA: special.2009.01.28

Stepping on such hallowed ground is a chance of a lifetime for fans on the annual pilgrimage.

BBC: News | UK | Name your Fab Four tops and flops

The organisers are billing it as "a chance of a lifetime" to perform in the Millennium Dome's central attraction to audiences of up to 12, 000 a show, six times a day.

BBC: News | Entertainment | It could be you at the Millennium show

When McPherson wasn't answering questions about Katie Holmes' guest turn on sophomore drama Eli Stone, he focused on the fall's two newcomers: Life on Mars, a British remake about a modern-day police detective who wakes up 35 years in the past, and Opportunity Knocks, a chance-of-a-lifetime game show from star Ashton Kutcher.

FORBES: Jimmy Kimmel Live