He well knew the futility of trying to contend against witches, so he gave up discouraged.

他深知与女巫斗争是徒劳无益的，所以他灰心丧气地放弃了。

youdao

The firm is too small to contend against [with] large international companies.

这家公司太小，无法与国际性的大公司抗争。

《新英汉大辞典》

They had to contend against drought.

他们必须跟干旱作斗争。

youdao

In an era where Danica Patrick can contend against men in motor sports, Silberman is about to take a big kick forward for female athletes, even if the odds are clearly stacked against her.

WSJ: Female kicker set for NFL regional combine tryout

Many also contend that inflation can work against fixed guaranteed withdrawal features.

FORBES: Aiming For Advisors

One of the plaintiff couples -- Paul Katami and Jeff Zarrillo of Burbank, California, who want to marry but can't because of Proposition 8 -- contend the state is discriminating against them because of their sexuality.

CNN: Day Two of same-sex marriage at Supreme Court