It will be a devastating blow to the local community if the factory closes.

如果这家工厂倒闭，将给当地居民以毁灭性的打击。

《牛津词典》

In September the AIDS community took a devastating blow when Merck halted an international human trial of the world's most promising potential vaccine against HIV.

今年9月，艾滋病研究因默克公司终止了世界上最有希望抵御艾滋病的疫苗的国际人体试验而遭受重大挫折。

youdao

Two decades later, the old, multi-ethnic character of Salonika took a final, devastating blow.

ECONOMIST: Religious tolerance

Japanese industries would suffer a devastating blow were Japan not to be a party to this agreement.

FORBES: Yomiuri's New Year's Editorial

The co-conspirators agreed to a pension termination that served them well but dealt a devastating blow to UAL employees.

FORBES: PBGC Pension Termination: A Worker's Perspective by Terry O'Rourke, United airlines (December 15, 2007 )